GLP-1 receptor analogue (research)
Semaglutide
Lyophilized research peptide
Long-acting GLP-1 receptor agonist analogue studied in vitro for incretin signaling, β-cell line response, and metabolic-pathway research. ≥99% HPLC. Research use only.
Lab name and RUO acknowledgment are collected at checkout.
Lot documentation
Every shipment includes the lot-specific certificate of analysis — HPLC purity (≥99% typical), mass-spec identity, net peptide content, water content, and residual solvents.
Identity & specifications
- Common name
- Semaglutide
- Origin
- GLP-1(7-37) analogue with C-18 di-acid acylation on Lys-26
- Molecular formula
- C187H291N45O59
- Molecular weight
- 4,113.58 g/mol
- Appearance
- White lyophilized powder
- Purity (HPLC)
- ≥ 99%
- Solubility
- Soluble in slightly alkaline lab buffers
Semaglutide in research
Semaglutide is a GLP-1(7-37) analogue with Aib substitution at position 8, Arg34→Lys, and a γ-Glu-2×OEG-C18 di-acid acylation on Lys-26. The substitution at position 8 confers in vitro stability against DPP-IV; the acylation extends in vitro half-life in published research. Common assay use covers receptor binding, β-cell line cAMP signaling, and metabolic-pathway studies in cell and animal model literature.
Identity and acyl-mass verification
Each lot is provided with ≥99% HPLC purity and MS identity verification covering backbone and acyl modification. Net peptide content is reported on the CoA. Labs running cross-analogue work commonly compare the acyl-mass delta against liraglutide and tirzepatide on the same assay plate; that data is filed by SKU.
Storage
Hold lyophilized vials at -20 °C sealed and protected from light. Reconstitute in lab-grade slightly alkaline buffer. Aliquot before freezing to limit freeze/thaw.
Documentation
CoA covers identity (MS), purity (HPLC), and net peptide content. Batch records by lot are filed against the SKU for procurement and compliance review.
Research guide
Semaglutide research overview
Semaglutide is a research-use-only material for qualified laboratory programs. This page summarizes identity fields, storage and handling, CoA review, and linked research resources for procurement and QA.
Catalog class: GLP-1 receptor analogue (research).
Key identity fields
- Common name
- Semaglutide
- Origin
- GLP-1(7-37) analogue with C-18 di-acid acylation on Lys-26
- Molecular formula
- C187H291N45O59
- Molecular weight
- 4,113.58 g/mol
- Appearance
- White lyophilized powder
- Purity (HPLC)
- ≥ 99%
Storage and handling
Handle Semaglutide as a lyophilized research reagent: cold, dry, light-protected storage; choose reconstitution buffer per your SOP; plan aliquots to limit freeze–thaw; and keep the lot CoA with the inventory record.
Research framing
Use Semaglutide in published model-system terms only — receptor family, pathway context, assay controls, and concentration planning. Do not transfer assumptions from adjacent peptides without a documented comparison protocol. Research use only.
Documentation checklist
- Storage and stability records for the received lot
- Lot CoA with HPLC, MS identity, and net peptide content
- Literature and assay context filed with the protocol
- Verify lots in the CoA Library
Product FAQ
Is Semaglutide intended for human or clinical use?
No. BluGen listings are research use only (RUO) for qualified laboratory programs — not clinical, diagnostic, therapeutic, veterinary, food, drug, or cosmetic use.
What documentation ships with Semaglutide?
Each lot includes a certificate of analysis with HPLC purity, MS identity confirmation, and net peptide content. Verify lots in the CoA Library.
Where can I verify the current-lot CoA for Semaglutide?
Search by compound or lot number in the CoA Library: https://getblugen.com/coa-library/
What sequence is listed for Semaglutide?
Verify sequence identity on the lot-specific CoA and identity table before use.
How should lyophilized Semaglutide be stored?
Store sealed vials cold, dry, and protected from light per the lot CoA and your institutional SOP. Aliquot reconstituted stock to limit freeze-thaw cycles.
Can institutions request a quote for Semaglutide?
Yes. Academic labs and CROs can request quotes and NET-30 billing after vendor qualification via the contact/procurement desk.
Where is the research guide for Semaglutide?
See the BluGen research guide for literature context, storage notes, and comparisons: https://getblugen.com/research/research-guide-semaglutide/
Related research resources
- Semaglutide research guide
- Research peptide glossary
- Peptide reconstitution guide
- Peptide storage and reconstitution guide
- How to read a peptide CoA
- HPLC, MS, and net peptide content guide
- Research use only procurement guide
- Related comparison guide
- Semaglutide procurement brief
- How to verify a peptide lot
- Supplier evaluation checklist
- Documentation hub
- Sample CoA field guide
Lab checklist
- Confirm lot CoA: HPLC purity, MS identity, and net peptide content before release.
- Record storage, reconstitution, concentration, and aliquot history per your SOP.
- Reconstitution calculator
- Documentation & verification hub
- Search PubMed for Semaglutide research
Research use only (RUO)
This material is sold for laboratory research purposes only. It is not for clinical, diagnostic, therapeutic, or veterinary application, and not for food, drug, or cosmetic use where restricted.
Related research & procurement docs
Research-use-only guides, comparisons, and procurement briefs tagged to this compound.
- Semaglutide research peptide procurement brief: GLP-1 analogue documentation checklist
- Tirzepatide vs Semaglutide: why two GLP-1 analogues that look identical produce different assay results
- Semaglutide: Research overview, identity, and laboratory handling guide
- Liraglutide vs Semaglutide: C16 palmitate vs C18 diacid, and the published half-life that follows