KPV: Research overview, identity, and laboratory handling guide

8 min read · Research use only

Written and reviewed by BluGen Research Team · Editorial standards

C-terminal α-MSH tripeptide Lys-Pro-Val. Lyophilized, 99% purity by HPLC. Reported in the literature for in vitro cytokine-signaling studies. Research use only. This guide covers identity, published research context, procurement checks, and storage — RUO only, no clinical claims.

What KPV is in published research

KPV is the carboxy-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH), comprising Lysine-Proline-Valine. The fragment has been studied in laboratory models for its observed interactions with NF-κB and downstream cytokine signaling, with reports across in vitro epithelial and immune-cell systems. As a short, sequence-defined tripeptide, KPV is a frequent reference standard in identity and purity work.

Procurement teams reviewing KPV typically check three things: confirmed sequence by mass spectrometry, HPLC purity at or above 99%, and a published net-peptide content (peptide-bound water and counter-ion removed). Our listing is structured so a buyer can attach a SKU- and lot-level certificate of analysis to a purchase order without manual reformatting.

Lyophilized KPV is shipped in clear borosilicate vials with a butyl stopper and aluminum overseal. For long-term storage, hold sealed vials at -20 °C protected from light. After reconstitution in bacteriostatic water or another lab-grade buffer, store at 2-8 °C and use within the working window your protocol specifies. Avoid repeated freeze/thaw of reconstituted aliquots.

Each shipment can be paired with a third-party certificate of analysis covering identity (MS), purity (HPLC), net-peptide content, and a moisture/residuals summary where in scope. Batch records are filed against the SKU so compliance teams can retrieve them in audit format.

The material class "Cytokine modulator (research)" helps procurement teams group KPV with related reference peptides during comparative studies.

Sequence and identity

KPV identity on the catalog: Sequence: H-Lys-Pro-Val-OH; Molecular formula: C16H30N4O4; Molecular weight: 342.44 g/mol; CAS: 67727-97-3; Appearance: White lyophilized powder; Purity (HPLC): ≥ 99%; Net peptide: Listed on CoA; Solubility: Soluble in bacteriostatic or sterile water for lab reconstitution. Copy these into receiving and LIMS before reconstitution.

Mechanisms studied in published research

Mechanism-focused research on KPV is typically conducted in cell lines or biochemical preparations that express the relevant receptor or binding protein for its class.

Design controls that include scrambled-sequence or orthogonal-receptor negative controls when your protocol evaluates KPV pharmacology in vitro.

Report effect sizes with lot number and CoA reference so results can be reproduced if the same KPV SKU is reordered later.

Avoid extrapolating in vitro binding or signaling readouts to whole-organism outcomes; RUO materials are not qualified for clinical investigation.

Procurement and identity verification

Request the lot-specific CoA for KPV at receipt. Verify SKU, variant size if applicable, and identity mass before the lot enters general storage.

Compare HPLC purity to your internal minimum for the peptide family. File chromatogram excerpts when your QMS requires raw data.

Enter net peptide content from the CoA into inventory before calculating molarity for KPV working stocks.

Attach purchase order, packing list, and CoA in one audit folder per lot.

Storage and reconstitution

Store lyophilized KPV sealed at -20 °C protected from light unless the CoA states otherwise.

Reconstitute with bacteriostatic water or a buffer validated for your assay pH. Aliquot to limit freeze-thaw.

For oxidation-sensitive sequences in KPV, minimize open-vial time at room temperature during weighing.

See our lyophilized storage guide for institution-scale SOP examples and aliquot labeling conventions.

Comparative reference points

Researchers comparing KPV with adjacent catalog references often evaluate the following SKUs in parallel plates:

Use matched reconstitution buffers and stock concentrations when running comparative binding or signaling assays.

Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.

When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.

Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.