Ipamorelin: Research overview, identity, and laboratory handling guide

Pentapeptide growth hormone secretagogue studied in vitro for selective GHS-R1a binding. ≥99% HPLC. Research use only. This guide covers identity, published research context, procurement checks, and storage — RUO only, no clinical claims.

What Ipamorelin is in published research

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue with reported selectivity for the GHS-R1a (ghrelin) receptor over melanocortin and other off-target receptors in published in vitro work. Labs use the peptide as a selectivity reference standard in receptor-binding and cAMP signaling assays alongside other secretagogues such as GHRP-2 and hexarelin.

Each lot ships with ≥99% HPLC purity and MS identity verification of the unnatural residues (Aib, D-2-Nal, D-Phe). Net peptide content is reported on the CoA. Comparative selectivity work commonly pairs ipamorelin with GHRP-2 on the same plate; that batch documentation can be filed by SKU.

Hold lyophilized vials at -20 °C sealed and protected from light. Reconstitute with bacteriostatic water; aliquot reconstituted stock into single-use volumes before freezing to limit freeze/thaw.

CoA covers identity (MS), purity (HPLC), and net peptide content. Batch records by lot are available for compliance review.

The material class "Growth hormone secretagogue (research)" helps procurement teams group Ipamorelin with related reference peptides during comparative studies.

Sequence and identity

Ipamorelin identity on the catalog: Common name: Ipamorelin; Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2; Length: 5 residues; Molecular formula: C38H49N9O5; Molecular weight: 711.86 g/mol; Appearance: White lyophilized powder; Purity (HPLC): ≥ 99%; Net peptide: Listed on CoA; Solubility: Soluble in bacteriostatic water. Copy these into receiving and LIMS before reconstitution.

Mechanisms studied in published research

Mechanism-focused research on Ipamorelin is typically conducted in cell lines or biochemical preparations that express the relevant receptor or binding protein for its class.

Design controls that include scrambled-sequence or orthogonal-receptor negative controls when your protocol evaluates Ipamorelin pharmacology in vitro.

Report effect sizes with lot number and CoA reference so results can be reproduced if the same Ipamorelin SKU is reordered later.

Avoid extrapolating in vitro binding or signaling readouts to whole-organism outcomes; RUO materials are not qualified for clinical investigation.

Procurement and identity verification

Request the lot-specific CoA for Ipamorelin at receipt. Verify SKU, variant size if applicable, and identity mass before the lot enters general storage.

Compare HPLC purity to your internal minimum for the peptide family. File chromatogram excerpts when your QMS requires raw data.

Enter net peptide content from the CoA into inventory before calculating molarity for Ipamorelin working stocks.

Attach purchase order, packing list, and CoA in one audit folder per lot.

Storage and reconstitution

Store lyophilized Ipamorelin sealed at -20 °C protected from light unless the CoA states otherwise.

Reconstitute with bacteriostatic water or a buffer validated for your assay pH. Aliquot to limit freeze-thaw.

For oxidation-sensitive sequences in Ipamorelin, minimize open-vial time at room temperature during weighing.

See our lyophilized storage guide for institution-scale SOP examples and aliquot labeling conventions.

Comparative reference points

Researchers comparing Ipamorelin with adjacent catalog references often evaluate the following SKUs in parallel plates:

Hexarelin (hexarelin) — compare identity table and CoA fields side by side.

Use matched reconstitution buffers and stock concentrations when running comparative binding or signaling assays.