CJC-1295 (No DAC): Research overview, identity, and laboratory handling guide
8 min read · Research use only
Written and reviewed by BluGen Research Team · Editorial standards
Modified GRF(1-29) analogue without Drug Affinity Complex. Studied in vitro for GHRH-receptor binding and short-half-life signaling research. ≥99% HPLC. Research use only. This guide covers identity, published research context, procurement checks, and storage — RUO only, no clinical claims.
What CJC-1295 (No DAC) is in published research
CJC-1295 without DAC, also known as Modified GRF(1-29), is a 29-residue GHRH analogue carrying four substitutions (D-Ala-2, Gln-8, Ala-15, Leu-27) that improve in vitro plasma stability relative to native GHRH while retaining activity at the GHRH receptor. Published research uses the peptide as a sequence-defined GHRH-R reference reagent in cell-line and ex-vivo pituitary preparations.
The "No DAC" form omits the Lys-30 maleimidopropionyl group that covalently binds albumin in the DAC variant. Research labs choose No DAC when they need a short-half-life GHRH analogue for time-course studies; the DAC variant is preferred when extended half-life dynamics are the subject. CoA reports identity (MS) and purity (HPLC) covering both backbone and absence of the DAC modification.
Hold lyophilized vials sealed at -20 °C protected from light. Reconstitute with bacteriostatic water for laboratory use; aliquot reconstituted stock into single-use working volumes before freezing. Avoid repeated freeze/thaw.
CoA covers identity (MS), purity (HPLC), and net peptide content. Batch records by lot are filed against the SKU for procurement and compliance review.
The material class "GHRH analogue (research)" helps procurement teams group CJC-1295 (No DAC) with related reference peptides during comparative studies.
Sequence and identity
CJC-1295 (No DAC) identity on the catalog: Common name: CJC-1295 No DAC (Modified GRF 1-29); Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2; Length: 29 residues; Molecular formula: C152H252N44O42; Molecular weight: 3,367.95 g/mol; Appearance: White lyophilized powder; Purity (HPLC): ≥ 99%; Net peptide: Listed on CoA; Solubility: Soluble in bacteriostatic water. Copy these into receiving and LIMS before reconstitution.
Mechanisms studied in published research
Mechanism-focused research on CJC-1295 (No DAC) is typically conducted in cell lines or biochemical preparations that express the relevant receptor or binding protein for its class.
Design controls that include scrambled-sequence or orthogonal-receptor negative controls when your protocol evaluates CJC-1295 (No DAC) pharmacology in vitro.
Report effect sizes with lot number and CoA reference so results can be reproduced if the same CJC-1295 (No DAC) SKU is reordered later.
Avoid extrapolating in vitro binding or signaling readouts to whole-organism outcomes; RUO materials are not qualified for clinical investigation.
Procurement and identity verification
Request the lot-specific CoA for CJC-1295 (No DAC) at receipt. Verify SKU, variant size if applicable, and identity mass before the lot enters general storage.
Compare HPLC purity to your internal minimum for the peptide family. File chromatogram excerpts when your QMS requires raw data.
Enter net peptide content from the CoA into inventory before calculating molarity for CJC-1295 (No DAC) working stocks.
Attach purchase order, packing list, and CoA in one audit folder per lot.
Storage and reconstitution
Store lyophilized CJC-1295 (No DAC) sealed at -20 °C protected from light unless the CoA states otherwise.
Reconstitute with bacteriostatic water or a buffer validated for your assay pH. Aliquot to limit freeze-thaw.
For oxidation-sensitive sequences in CJC-1295 (No DAC), minimize open-vial time at room temperature during weighing.
See our lyophilized storage guide for institution-scale SOP examples and aliquot labeling conventions.
Comparative reference points
Researchers comparing CJC-1295 (No DAC) with adjacent catalog references often evaluate the following SKUs in parallel plates:
Use matched reconstitution buffers and stock concentrations when running comparative binding or signaling assays.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Document reviewers should cross-link this guide with the product certificate of analysis and internal receiving SOP.
When publishing methods, cite lot number, SKU, reconstitution buffer, and stock concentration so external labs can interpret your figures.
Institutional procurement may require RUO acknowledgment at checkout; store that acknowledgment beside batch records for audits.
If assay results drift across quarters, compare storage logs and CoA revision before questioning sequence integrity.
Third-party summaries, when available, should be filed as supplements—not replacements—for CoA identity data.
Frequently asked questions
Is CJC-1295 (No DAC) for clinical programs?
No. It is sold for research use only (RUO) to qualified buyers.
What purity should we expect for CJC-1295 (No DAC)?
Listings target ≥99% HPLC with MS identity on the lot CoA. Verify on receipt, not from marketing copy alone.
How do we calculate molarity for CJC-1295 (No DAC)?
Use net peptide content from the CoA divided by molecular weight, then divide by reconstitution volume.
Can we mix lots of CJC-1295 (No DAC) in one stock?
Avoid mixing lots unless your protocol explicitly requires it. Mixed lots break traceability.
Where is the CJC-1295 (No DAC) product listing?
View the catalog PDP for CJC-1295 (No DAC) for variant SKUs and quote or purchase options.
Citation
BluGen Research Peptides — CJC-1295 (No DAC): Research overview, identity, and laboratory handling guide. https://getblugen.com/research/research-guide-cjc-1295-no-dac/. Accessed 2026-06-14.
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