Adipotide (FTPP): Research overview, identity, and laboratory handling guide

Proapoptotic peptidomimetic studied in vitro and in animal models for prohibitin-targeted adipose-vasculature research. Lyophilized, ≥99% HPLC. Research use only. This guide covers identity, published research context, procurement checks, and storage — RUO only, no clinical claims.

What Adipotide (FTPP) is in published research

Adipotide is a chimeric peptidomimetic combining a CKGGRAKDC prohibitin-binding sequence with a D-amino-acid (KLAKLAK)2 proapoptotic motif. Published research has examined the construct in animal models for white-adipose vasculature targeting, with downstream apoptosis of associated endothelial cells in published in vivo studies.

Each lot ships with HPLC purity at ≥99% and MS identity verification covering both the targeting and proapoptotic motifs. Net peptide content is reported on the CoA.

Hold lyophilized vials sealed at -20 °C away from light. Reconstitute with bacteriostatic water; the construct is sensitive to repeated freeze/thaw, so aliquoting before freezing is recommended.

CoA, batch records, and lot-level identity reporting are filed by SKU.

The material class "Proapoptotic targeting peptide (research)" helps procurement teams group Adipotide (FTPP) with related reference peptides during comparative studies.

Sequence and identity

Adipotide (FTPP) identity on the catalog: Common name: Adipotide / FTPP (Fat-Targeted Proapoptotic Peptide); Structure: CKGGRAKDC-GG-D(KLAKLAK)2; Targeting motif: CKGGRAKDC (prohibitin-binding); Proapoptotic motif: D(KLAKLAK)2; Appearance: White lyophilized powder; Purity (HPLC): ≥ 99%; Solubility: Soluble in bacteriostatic water. Copy these into receiving and LIMS before reconstitution.

Mechanisms studied in published research

Mechanism-focused research on Adipotide (FTPP) is typically conducted in cell lines or biochemical preparations that express the relevant receptor or binding protein for its class.

Design controls that include scrambled-sequence or orthogonal-receptor negative controls when your protocol evaluates Adipotide (FTPP) pharmacology in vitro.

Report effect sizes with lot number and CoA reference so results can be reproduced if the same Adipotide (FTPP) SKU is reordered later.

Avoid extrapolating in vitro binding or signaling readouts to whole-organism outcomes; RUO materials are not qualified for clinical investigation.

Procurement and identity verification

Request the lot-specific CoA for Adipotide (FTPP) at receipt. Verify SKU, variant size if applicable, and identity mass before the lot enters general storage.

Compare HPLC purity to your internal minimum for the peptide family. File chromatogram excerpts when your QMS requires raw data.

Enter net peptide content from the CoA into inventory before calculating molarity for Adipotide (FTPP) working stocks.

Attach purchase order, packing list, and CoA in one audit folder per lot.

Storage and reconstitution

Store lyophilized Adipotide (FTPP) sealed at -20 °C protected from light unless the CoA states otherwise.

Reconstitute with bacteriostatic water or a buffer validated for your assay pH. Aliquot to limit freeze-thaw.

For oxidation-sensitive sequences in Adipotide (FTPP), minimize open-vial time at room temperature during weighing.

See our lyophilized storage guide for institution-scale SOP examples and aliquot labeling conventions.

Comparative reference points

Researchers comparing Adipotide (FTPP) with adjacent catalog references often evaluate the following SKUs in parallel plates:

Use matched reconstitution buffers and stock concentrations when running comparative binding or signaling assays.