GLP-1 receptor analogue (research)
Semaglutide
Lyophilized research peptide
Long-acting GLP-1 receptor agonist analogue studied in vitro for incretin signaling, β-cell line response, and metabolic-pathway research. ≥99% HPLC. Research use only.
Lab name and RUO acknowledgment are collected at checkout.
Lot documentation
Every shipment includes the lot-specific certificate of analysis — HPLC purity (≥99% typical), mass-spec identity, net peptide content, water content, and residual solvents.
Identity & specifications
- Common name
- Semaglutide
- Origin
- GLP-1(7-37) analogue with C-18 di-acid acylation on Lys-26
- Molecular formula
- C187H291N45O59
- Molecular weight
- 4,113.58 g/mol
- Appearance
- White lyophilized powder
- Purity (HPLC)
- ≥ 99%
- Solubility
- Soluble in slightly alkaline lab buffers
Semaglutide in research
Semaglutide is a GLP-1(7-37) analogue with Aib substitution at position 8, Arg34→Lys, and a γ-Glu-2×OEG-C18 di-acid acylation on Lys-26. The substitution at position 8 confers in vitro stability against DPP-IV; the acylation extends in vitro half-life in published research. Common assay use covers receptor binding, β-cell line cAMP signaling, and metabolic-pathway studies in cell and animal model literature.
Identity and acyl-mass verification
Each lot is provided with ≥99% HPLC purity and MS identity verification covering backbone and acyl modification. Net peptide content is reported on the CoA. Labs running cross-analogue work commonly compare the acyl-mass delta against liraglutide and tirzepatide on the same assay plate; that data is filed by SKU.
Storage
Hold lyophilized vials at -20 °C sealed and protected from light. Reconstitute in lab-grade slightly alkaline buffer. Aliquot before freezing to limit freeze/thaw.
Documentation
CoA covers identity (MS), purity (HPLC), and net peptide content. Batch records by lot are filed against the SKU for procurement and compliance review.
Research guide
Semaglutide research overview
Semaglutide is listed as a research-use-only material for qualified laboratory programs. This page connects the product listing with identity fields, storage context, CoA review, and long-form research resources so procurement and QA reviewers can evaluate the SKU without relying on a thin commerce page.
The catalog classifies this material as GLP-1 receptor analogue (research), which helps labs compare it with adjacent research peptides, organize internal inventory, and build study-specific reference groups.
Key identity fields
- Common name
- Semaglutide
- Origin
- GLP-1(7-37) analogue with C-18 di-acid acylation on Lys-26
- Molecular formula
- C187H291N45O59
- Molecular weight
- 4,113.58 g/mol
- Appearance
- White lyophilized powder
- Purity (HPLC)
- ≥ 99%
Storage and handling context
For long-tail stability searches, Semaglutide should be evaluated in the context of lyophilized storage, reconstitution buffer choice, aliquot planning, freeze-thaw limits, and lot-specific CoA conditions. Always follow institutional SOPs and the documentation attached to the received lot.
Mechanism context
Semaglutide should be described through published model-system language: receptor family, pathway context, assay controls, concentration planning, and lot traceability. Avoid transferring assumptions from adjacent peptides without a documented comparison protocol.
Search intent covered
- Semaglutide storage and stability
- Semaglutide CoA and identity
- Semaglutide mechanism research
- Semaglutide comparison resources
Product FAQ
Is Semaglutide intended for clinical programs?
No. BluGen listings are research use only (RUO) materials for qualified laboratory programs, not clinical, diagnostic, therapeutic, veterinary, food, drug, or cosmetic use.
What documentation is available for Semaglutide?
Lot-level documentation may include CoA, HPLC purity, MS identity confirmation, net peptide content, and batch records where available for the SKU and lot.
How should lyophilized Semaglutide be stored?
Store sealed lyophilized vials cold, dry, and protected from light unless the lot CoA or institutional SOP specifies another condition. Reconstituted material should be aliquoted according to the lab protocol.
Where can I learn more about Semaglutide research context?
See the BluGen research guide for mechanism context, stability notes, storage considerations, and related peptide comparisons: https://getblugen.com/research/research-guide-semaglutide/
What is the research category for Semaglutide?
Semaglutide is categorized as GLP-1 receptor analogue (research) for catalog organization, internal linking, and related research comparisons.
What sequence is listed for Semaglutide?
Sequence identity should be verified against the lot-specific CoA and product identity table before release into a research workflow.
What molecular weight is listed for Semaglutide?
The listed molecular weight for Semaglutide is 4,113.58 g/mol. Use the lot CoA and net peptide content when calculating research stock concentrations.
Does Semaglutide require cold storage?
Most lyophilized research peptides are stored cold, dry, sealed, and protected from light unless the lot CoA or institutional SOP states otherwise.
How should reconstituted Semaglutide be handled?
Reconstituted research stocks should be labeled with SKU, lot, solvent, concentration, date, and technician initials, then aliquoted according to the lab protocol to limit freeze-thaw history.
Can lots of Semaglutide be mixed together?
Avoid mixing lots unless a written protocol requires it. Mixed-lot stocks reduce traceability and make CoA review more difficult.
What purity documentation matters for Semaglutide?
HPLC purity, MS identity, net peptide content, moisture or residual summaries where available, and lot number alignment are the core documentation checks.
What does net peptide content mean for Semaglutide?
Net peptide content accounts for peptide mass apart from water and counter-ion contribution. It is important for molarity calculations in laboratory records.
What should procurement review before ordering Semaglutide?
Procurement should review SKU, vial size, lot documentation path, RUO status, storage requirements, shipping expectations, and any internal approval requirements.
How should Semaglutide be cited in a method record?
Record supplier, SKU, lot number, CoA document ID, reconstitution solvent, stock concentration, storage condition, and date prepared.
What are common related resources for Semaglutide?
Related resources include the peptide storage guide, reconstitution guide, CoA reading guide, purity guide, and any comparison articles linked from the product page.
Why does BluGen link Semaglutide to research articles?
Internal article links help buyers evaluate identity, storage, documentation, and research context without relying on a thin product listing.
What should be done if Semaglutide documentation is incomplete?
Hold the lot in review and request the missing CoA or batch documentation before releasing the material into an internal research workflow.
Is Semaglutide content on BluGen medical advice?
No. BluGen content is laboratory procurement and research documentation content for RUO materials only.
Related research resources
Reference path
- Lot CoA: verify HPLC purity, MS identity, and net peptide before release.
- Internal SOP: record storage, reconstitution, concentration, and aliquot history.
- Reconstitution calculator: convert vial size + diluent to concentration
- Article links: file the product guide, glossary definition, storage guide, and comparison page beside procurement notes.
- Search PubMed for Semaglutide research
Research use only (RUO)
This material is sold for laboratory research purposes only. It is not for clinical, diagnostic, therapeutic, or veterinary application, and not for food, drug, or cosmetic use where restricted.